66.0
ISS Score
Moderate — Score based on regulatory approval status in 4 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance agent · skin conditioning agent · aromatic compound · solvent
ACETYLATED VETIVER OIL
Category
essential oil
Bottom Line: Acetylated vetiver oil is generally considered safe for use in cosmetics and food, though individual reactions may vary.
Quick Answer
✔ Generally Safe If:
- Used in diluted form in cosmetic products
- Ingested in small amounts as a flavoring agent
- Used in well-formulated products with safety assessments
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- You are pregnant or nursing
- You are using other products containing essential oils
✕ Avoid If:
- You have a known allergy to vetiver or similar oils
- You are using it in high concentrations
- You experience irritation or adverse reactions
Chemical Properties
| Property | Value |
|---|
Common Use Cases
4 Categories
Cosmetic
Fragrance oils, skin creams, soaps. Generally safe in diluted cosmetic formulations.
Food
Flavoring agents, beverages. Use in moderation as a flavoring agent.
Pharmaceutical
Aromatherapy oils, topical treatments. Consult a healthcare provider for medicinal use.
Supplement
Herbal supplements. Use under guidance of a healthcare professional.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Acetylated vetiver oil is generally safe for skin contact, with low irritation potential.
oral
oral
Risk Level: Moderate
Ingestion of acetylated vetiver oil may cause gastrointestinal discomfort in some individuals.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low risk, but may cause irritation in sensitive individuals.
ocular
ocular
Risk Level: High
Eye contact with acetylated vetiver oil can cause significant irritation and discomfort.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher risk of irritation and adverse reactions.
- pregnant — Limited safety data; caution advised.
✔ Well-Tolerated Groups
- general_adult — Generally well tolerated with low risk.
- breastfeeding — Low to moderate risk; consult healthcare provider.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on safety during pregnancy; use with caution. |
| infants_children | High | Higher sensitivity in young children; potential for adverse reactions. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; use cautiously. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Acetylated vetiver oil has been evaluated for safety in cosmetics and food applications, showing low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 18600 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Human patch test | No significant irritation observed | CIR Safety Assessment (2015) |
| Sensitization | not sensitizing | Human sensitization study | No sensitization reactions reported | CIR Safety Assessment (2015) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Acetylated vetiver oil has been evaluated for safety in cosmetics and food applications, showing low toxicity.
- Generally recognized as safe in cosmetic formulations.
- Low acute toxicity in animal studies.
- Limited data on long-term effects.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Acetylated Vetiver Oil
Year: 2015
Conclusion: Safe for use in cosmetics at recommended concentrations.
View Full Report →
EFSA
Report: Scientific Opinion on Acetylated Vetiver Oil
Year: 2018
Conclusion: Considered safe for use in food flavoring at specified limits.
View Full Report →
FDA
Report: Regulatory Status of Acetylated Vetiver Oil
Year: 2020
Conclusion: Permitted for use in food and cosmetics under specified conditions.
View Full Report →
Regulatory Status
Global
Acetylated vetiver oil is permitted for use in cosmetics and food across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should perform a patch test first.
It is typically safe in small amounts as a flavoring, but consult a healthcare provider first.
Discontinue use immediately and consult a healthcare professional if irritation persists.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-19T17:30:01.019979Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.