66.0
ISS Score
Moderate — Score based on regulatory approval status in 4 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance agent · antimicrobial agent · skin conditioning agent · flavoring agent
Citrus Limon Peel Oil
Also known as: Lemon Peel Oil, Citrus Limon Oil, Lemon Oil
Molecular Formula
C222H230N14O23S2
Molecular Weight
3526 g/mol
Category
essential oil
Bottom Line: Citrus Limon Peel Oil is generally considered safe for use in cosmetics and food, though some individuals may experience sensitivity.
Quick Answer
✔ Generally Safe If:
- used in diluted form in cosmetics
- consumed in food products within recommended limits
- not applied to broken skin
- used in well-ventilated areas
⚠ Use with Awareness If:
- you have citrus allergies
- you are pregnant or nursing
- you have sensitive skin
- you are using other skin irritants
✕ Avoid If:
- you have a known allergy to citrus oils
- you are applying it near the eyes
- you are using it on open wounds
- you are exposed to direct sunlight after application
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C222H230N14O23S2 |
| Molecular Weight | 3526 g/mol |
Common Use Cases
4 Categories
Cosmetic
Facial creams, shampoos, body lotions, soaps. Dilute before use to minimize irritation risk.
Food
Flavoring agents, beverages, confectionery. Use within recommended food safety limits.
Pharmaceutical
Topical ointments, medicated creams. Consult a healthcare provider for medicinal use.
Supplement
Dietary supplements, herbal teas. Follow dosage recommendations to avoid adverse effects.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Citrus Limon Peel Oil is generally safe for skin contact but may cause irritation in sensitive individuals.
oral
oral
Risk Level: Moderate
Ingestion of Citrus Limon Peel Oil can cause gastrointestinal discomfort in some individuals.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation of Citrus Limon Peel Oil may cause respiratory irritation in sensitive individuals.
ocular
ocular
Risk Level: High
Contact with eyes can cause significant irritation and discomfort; caution is advised.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher risk of irritation and adverse reactions.
- sensitive_skin — Increased likelihood of skin irritation.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal adverse effects.
- breastfeeding — Generally safe with monitoring for reactions.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated; however, some may experience skin irritation. |
| pregnant | Moderate | Limited data on safety during pregnancy; use with caution. |
| infants_children | High | Higher sensitivity to essential oils; risk of irritation is significant. |
| breastfeeding | Low to Moderate | Limited data on effects during breastfeeding; use cautiously. |
| sensitive_skin | High | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Citrus Limon Peel Oil is widely used in cosmetics and food, with safety assessments indicating low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 18600 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2012) |
| Skin Irritation | non-irritating | Human patch test | Not a skin irritant | CIR Safety Assessment (2012) |
| Sensitization | non-sensitizing | Human patch test | No sensitization observed | CIR Safety Assessment (2012) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Citrus Limon Peel Oil is widely used in cosmetics and food, with safety assessments indicating low toxicity.
- Generally recognized as safe in food applications.
- May cause skin irritation in sensitive individuals.
- Used in various cosmetic formulations.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Citrus Limon Peel Oil
Year: 2012
Conclusion: Citrus Limon Peel Oil is safe for use in cosmetics at concentrations up to 5%.
View Full Report →
EFSA
Report: Scientific Opinion on Citrus Limon Peel Oil
Year: 2015
Conclusion: Citrus Limon Peel Oil is safe for use in food at specified limits.
View Full Report →
FDA
Report: Food Ingredients and Colors
Year: 2020
Conclusion: Citrus Limon Peel Oil is generally recognized as safe for use in food.
View Full Report →
Regulatory Status
Global
Citrus Limon Peel Oil is permitted for use in cosmetics and food across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionPERMITTED
None
UK
UK GovernmentPERMITTED
None
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, it may cause irritation for sensitive skin types. Patch testing is recommended.
Yes, it is generally recognized as safe for food use, but should be consumed in moderation.
Discontinue use immediately and consult a healthcare professional if irritation persists.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-29T07:04:27.591470Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.