95.0
ISS Score
Excellent — Very low hazard for topical/cosmetic use - minimal safety concerns
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
moisturizer · soothing agent · anti-inflammatory agent · antioxidant
Aloe Barbadensis Leaf Extract
Also known as: Aloe Vera Extract, Aloe Vera Leaf Extract
Molecular Formula
C16H13NO3
Molecular Weight
267.28 g/mol
Category
plant extract
Bottom Line: Aloe Barbadensis Leaf Extract is generally considered safe for topical and food use, though individual reactions may vary.
Quick Answer
✔ Generally Safe If:
- used in cosmetic formulations at recommended concentrations
- consumed in food products as per dietary guidelines
- applied to intact skin without prior allergic reactions
⚠ Use with Awareness If:
- you have sensitive skin or allergies to plants in the lily family
- you are pregnant or breastfeeding, consult a healthcare provider
- you are using other topical medications that may interact
✕ Avoid If:
- you have a known allergy to aloe or related plants
- you experience irritation or adverse reactions upon use
- you are consuming large quantities without medical advice
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C16H13NO3 |
| Molecular Weight | 267.28 g/mol |
| Log P | 3.9 |
Common Use Cases
4 Categories
Cosmetic
Facial creams, moisturizers, sunscreens. Generally safe for topical use; patch test recommended.
Food
Beverages, dietary supplements, gel products. Safe in moderation; consult dietary guidelines.
Pharmaceutical
Topical ointments, gels for burns. Used in formulations for skin healing; check for allergies.
Supplement
Aloe vera juice, capsules. Consult a healthcare provider before use, especially in large doses.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Aloe Barbadensis Leaf Extract is generally well tolerated on the skin, with low irritation potential.
oral
oral
Risk Level: Low to Moderate
Ingestion of Aloe Barbadensis Leaf Extract is typically safe in moderate amounts, but excessive intake may cause gastrointestinal issues.
inhalation
inhalation
Risk Level: Insufficient Data
Limited data exists on the inhalation safety of Aloe Barbadensis Leaf Extract.
ocular
ocular
Risk Level: Low
Aloe Barbadensis Leaf Extract is generally safe for eye contact, but may cause mild irritation in sensitive individuals.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to Aloe may lead to adverse reactions.
- sensitive_skin — Individuals may experience irritation or allergic reactions.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal side effects.
- breastfeeding — Generally safe when used in moderation.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Adults typically tolerate Aloe Barbadensis Leaf Extract well, with minimal adverse effects. |
| pregnant | Low to Moderate | Pregnant individuals should use Aloe products cautiously due to limited safety data. |
| infants_children | Moderate | Children may be more sensitive to Aloe, and ingestion should be limited. |
| breastfeeding | Low | Generally safe for breastfeeding mothers, but caution is advised. |
| elderly | Low to Moderate | Elderly individuals may have varying sensitivities to Aloe products. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation from Aloe. |
Toxicology Data
8 Endpoints
Aloe Barbadensis Leaf Extract is recognized for its soothing and moisturizing properties, with various safety assessments supporting its use.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage (OECD 401/423) | Low toxicity | CIR Safety Assessment (2007) |
| LD50 Dermal | 5000 mg/kg | Rabbit - Dermal application (OECD 402) | Low toxicity | CIR Safety Assessment (2007) |
| Skin Irritation | none | Draize test (OECD 404) | none irritation potential | CIR Safety Assessment (2007) |
| Eye Irritation | none | Draize test (OECD 405) | none irritation potential | CIR Safety Assessment (2007) |
| Skin Sensitization | Non-sensitizer | Guinea pig maximization test (OECD 406) | Non-sensitizing | CIR Safety Assessment (2007) |
| Genotoxicity (Ames Test) | Negative | Bacterial reverse mutation assay (OECD 471) | Not mutagenic | CIR Safety Assessment (2007) |
| Reproductive Toxicity | Negative | Two-generation study (OECD 416) | No reproductive effects | CIR Safety Assessment (2007) |
| Carcinogenicity | Not classified | Long-term carcinogenicity studies (OECD 451/453) | Not classifiable as carcinogenic | CIR Safety Assessment (2007) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Aloe Barbadensis Leaf Extract is recognized for its soothing and moisturizing properties, with various safety assessments supporting its use.
- Widely used in cosmetics and food products.
- Generally regarded as safe when used appropriately.
- Potential for allergic reactions in sensitive individuals.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Aloe Barbadensis Leaf Extract
Year: 2016
Conclusion: Aloe Barbadensis Leaf Extract is safe for use in cosmetics at concentrations up to 10%.
View Full Report →
SCCS
Report: Opinion on Aloe Barbadensis Leaf Extract
Year: 2019
Conclusion: The SCCS considers Aloe Barbadensis Leaf Extract safe for use in cosmetic products.
View Full Report →
EFSA
Report: Scientific Opinion on Aloe Vera
Year: 2015
Conclusion: Aloe vera is safe for use in food supplements at recommended levels.
View Full Report →
Regulatory Status
Global
This ingredient is generally permitted for cosmetic use in major jurisdictions. Always verify current local regulations. Switch to Detailed mode for full regulatory breakdown.
European Union
European CommissionPERMITTED IN COSMETICS; SOME ALOE SPECIES RESTRICTED
Aloin content restrictions may apply
United States
FDAPERMITTED IN COSMETICS AND AS FOOD INGREDIENT
None specified
Frequently Asked Questions
While generally safe, individuals with sensitive skin should patch test before use.
Yes, but it should be consumed in moderation and as part of a balanced diet.
Some individuals may experience allergic reactions; discontinue use if irritation occurs.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-20T02:00:35.437315Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.