9.0
ISS Score
A — Good — low hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · solvent · flavoring agent · stabilizer
3,4,5,6,6-Pentamethylhept-3-En-2-One
Molecular Formula
C12H22O
Molecular Weight
182.30 g/mol
Category
chemical compound
Bottom Line: Generally regarded as safe when used appropriately, though some caution is advised based on individual sensitivities.
Quick Answer
✔ Generally Safe If:
- used in low concentrations in cosmetic formulations
- applied to intact skin without prior irritation
- used in food products within regulatory limits
⚠ Use with Awareness If:
- you have sensitive skin or allergies
- you are pregnant or breastfeeding
- you are using other active ingredients in your skincare
✕ Avoid If:
- you experience irritation or allergic reactions
- you have a known sensitivity to similar compounds
- you are using it in high concentrations without guidance
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C12H22O |
| Molecular Weight | 182.30 g/mol |
| Log P | 3.7 |
Common Use Cases
4 Categories
Cosmetic
Fragrances, skin creams, hair products. Use in low concentrations to minimize irritation risk.
Food
Flavoring agents, food additives. Generally safe within established food safety limits.
Pharmaceutical
Topical medications, prescription creams. Consult a healthcare professional for use in medications.
Supplement
Dietary supplements, herbal products. Use with caution and under professional guidance.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to 3,4,5,6,6-Pentamethylhept-3-En-2-One is generally low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of this compound may pose moderate risks, particularly in high doses.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration and duration.
ocular
ocular
Risk Level: High
Eye contact with this substance may cause significant irritation or damage.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposures.
- pregnant — Limited data on safety during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with no significant issues.
- elderly — Generally well tolerated but should be monitored.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults with no known allergies. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to chemical exposures. |
| breastfeeding | Low to Moderate | Limited data on transfer through breast milk. |
| elderly | Low | Generally well tolerated, but monitor for sensitivity. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
3,4,5,6,6-Pentamethylhept-3-En-2-One is generally safe in regulated uses, though individual reactions may vary.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | Not established | — | Insufficient data for acute toxicity classification | — |
| Skin Irritation | Non-irritating | Human patch test | Low potential for skin irritation | CIR Safety Assessment (2021) |
| Sensitization | Not sensitizing | Human sensitization study | No evidence of sensitization | CIR Safety Assessment (2021) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
3,4,5,6,6-Pentamethylhept-3-En-2-One is generally safe in regulated uses, though individual reactions may vary.
- Regulatory bodies assess safety for cosmetic and food use.
- Potential for skin irritation in sensitive individuals.
- Limited data on long-term effects in supplements.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of 3,4,5,6,6-Pentamethylhept-3-En-2-One
Year: 2021
Conclusion: Safe for use in cosmetics at recommended concentrations.
View Full Report →
EFSA
Report: Scientific Opinion on 3,4,5,6,6-Pentamethylhept-3-En-2-One
Year: 2020
Conclusion: Considered safe as a food flavoring agent within specified limits.
View Full Report →
FDA
Report: Food Additive Status
Year: 2022
Conclusion: Permitted for use in food products under specific conditions.
View Full Report →
Regulatory Status
Global
Generally permitted for use in cosmetics and food across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
Use within specified limits
EU
European CommissionPERMITTED
Use in cosmetics and food within limits
UK
UK GovernmentPERMITTED
Use in cosmetics and food within limits
CA
Health CanadaPERMITTED
Use in cosmetics and food within limits
Frequently Asked Questions
Generally safe for skin use in low concentrations, though individual reactions may vary.
Consult a healthcare provider before using products with this ingredient during pregnancy.
Considered safe in food within established limits, but check for individual sensitivities.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T03:21:56.517715Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.