7.0
ISS Score
A- — Good — low to minimal hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · solvent · fixative · flavoring agent
2-T-Butylcyclohexyl Acetate
Molecular Formula
C12H22O2
Molecular Weight
198.30 g/mol
Category
fragrance
Bottom Line: 2-T-Butylcyclohexyl Acetate is generally considered safe in cosmetics and household products, though caution is advised for sensitive individuals.
Quick Answer
✔ Generally Safe If:
- Used in low concentrations in cosmetic formulations
- Not applied to broken or irritated skin
- Used in well-ventilated areas for household products
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using in combination with other fragrances
- You are pregnant or nursing
✕ Avoid If:
- You have a known allergy to similar compounds
- Using on children without prior testing
- You experience irritation or adverse reactions
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C12H22O2 |
| Molecular Weight | 198.30 g/mol |
| Log P | 3.6 |
Common Use Cases
5 Categories
Cosmetic
Fragrances, lotions, shampoos. Generally safe in cosmetic products when used as directed.
Food
Flavoring agents, food additives. Use in food is limited; check for specific regulations.
Pharmaceutical
Topical creams, ointments. Use with caution in pharmaceuticals; consult a professional.
Household
Air fresheners, cleaning products. Ensure good ventilation when using household products.
Supplement
Dietary supplements. Limited use in supplements; consult a healthcare provider.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to 2-T-Butylcyclohexyl Acetate is generally low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of 2-T-Butylcyclohexyl Acetate may pose moderate risks, particularly in large amounts.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration and duration.
ocular
ocular
Risk Level: High
Eye contact with 2-T-Butylcyclohexyl Acetate can cause irritation and is considered high risk.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposures.
- pregnant — Limited data on safety during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with proper use.
- elderly — Generally well tolerated, but monitor for sensitivities.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated by adults, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to chemical exposures. |
| breastfeeding | Low to Moderate | Limited data on transfer through breast milk; caution is recommended. |
| elderly | Low | Generally well tolerated, but age-related sensitivities may apply. |
Toxicology Data
3 Endpoints
2-T-Butylcyclohexyl Acetate has been evaluated for safety in cosmetics and food applications, showing low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 18600 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | Not irritating | SCCS Opinion (2018) |
| Sensitization | non-sensitizing | Guinea Pig - Maximization Test | Not sensitizing | CIR Safety Assessment (2015) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
2-T-Butylcyclohexyl Acetate has been evaluated for safety in cosmetics and food applications, showing low toxicity.
- Low acute toxicity in animal studies.
- Generally recognized as safe in cosmetic use.
- Limited data for food applications.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Fragrance Ingredients
Year: 2015
Conclusion: Safe for use in cosmetics at concentrations up to 5%.
View Full Report →
SCCS
Report: Opinion on Fragrance Ingredients
Year: 2018
Conclusion: Considered safe for use in cosmetics with restrictions.
View Full Report →
EFSA
Report: Scientific Opinion on Flavoring
Year: 2017
Conclusion: Insufficient data to determine safety in food applications.
View Full Report →
Regulatory Status
Global
2-T-Butylcyclohexyl Acetate is permitted in the US, UK, and Canada, with restrictions in the EU. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionRESTRICTED
Limited use in cosmetics
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should perform a patch test before use.
Consult a healthcare provider before using products with this ingredient during pregnancy.
Potential side effects include skin irritation or allergic reactions in sensitive individuals.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T03:16:55.318511Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.