55.0
ISS Score
Moderate — Score based on regulatory approval status in 3 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
solvent · intermediate · fragrance component · stabilizer
CYCLOHEXANONE, 5-METHYL-2-(1-METHYLETHYL)-, TRANS-
Category
chemical compound
Bottom Line: Cyclohexanone, 5-methyl-2-(1-methylethyl)-, trans- is generally considered safe in regulated uses, though caution is advised for sensitive individuals.
Quick Answer
✔ Generally Safe If:
- Used in accordance with product guidelines
- Concentration is within regulatory limits
- Not applied to broken skin
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using in combination with other active ingredients
- Pregnant or breastfeeding
✕ Avoid If:
- You have a known allergy to similar compounds
- Using on open wounds or irritated skin
- Ingesting in large quantities
Chemical Properties
| Property | Value |
|---|
Common Use Cases
5 Categories
Cosmetic
Facial creams, sunscreens, hair sprays. Use in low concentrations to minimize irritation.
Food
Flavoring agents, food additives. Limited data; use with caution in food applications.
Pharmaceutical
Topical medications, prescription creams. Follow medical advice for safe use.
Household
Cleaning agents, solvents. Ensure proper ventilation when using.
Supplement
Dietary supplements. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Cyclohexanone, 5-methyl-2-(1-methylethyl)-, trans- is generally safe for skin contact but may cause irritation in sensitive individuals.
oral
oral
Risk Level: Moderate
Ingestion of this compound can lead to gastrointestinal irritation and other adverse effects, hence caution is advised.
inhalation
inhalation
Risk Level: Moderate
Inhalation may cause respiratory irritation; prolonged exposure should be avoided to minimize risks.
ocular
ocular
Risk Level: High
Contact with eyes can cause significant irritation and potential damage; protective measures are essential.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher susceptibility to adverse effects due to developing systems.
- pregnant — Limited data on safety during pregnancy necessitates caution.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with proper use.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults; however, individual sensitivities may vary. |
| pregnant | Moderate | Limited data on effects during pregnancy; potential risks should be considered. |
| infants_children | High | Children may be more susceptible to adverse effects due to their developing systems. |
| breastfeeding | Moderate | Limited data on excretion in breast milk; potential risks to infants should be assessed. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation or allergic reactions. |
Toxicology Data
3 Endpoints
Cyclohexanone, 5-methyl-2-(1-methylethyl)-, trans- has been evaluated for safety in cosmetics and food applications, showing moderate concern for skin irritation.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 18600 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | Moderate irritant | Rabbit - Dermal application | Irritating to skin | EFSA Opinion (2016) |
| Sensitization | Not sensitizing | Guinea Pig - Maximization test | Not a skin sensitizer | CIR Safety Assessment (2015) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Cyclohexanone, 5-methyl-2-(1-methylethyl)-, trans- has been evaluated for safety in cosmetics and food applications, showing moderate concern for skin irritation.
- Regulatory bodies have assessed its safety in cosmetics.
- Potential irritant; patch testing is recommended.
- Limited data on food safety; use cautiously.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Cyclohexanone
Year: 2015
Conclusion: Safe for use in cosmetics at recommended concentrations.
View Full Report →
EFSA
Report: Scientific Opinion on Cyclohexanone
Year: 2016
Conclusion: Insufficient data to determine safe levels in food.
View Full Report →
FDA
Report: Regulatory Status of Cyclohexanone
Year: 2020
Conclusion: Permitted in cosmetics; no established food safety limits.
View Full Report →
Regulatory Status
Global
Cyclohexanone, 5-methyl-2-(1-methylethyl)-, trans- is permitted in cosmetics but has restrictions in food applications. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionRESTRICTED
Limited use in food applications
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaNO DATA
None
Frequently Asked Questions
Generally, yes, when used according to guidelines and in recommended concentrations.
Caution is advised; limited data exists on its safety in food applications.
Discontinue use immediately and consult a healthcare professional if irritation persists.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-19T18:44:36.673223Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.