66.0
ISS Score
Moderate — Score based on regulatory approval status in 4 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
solvent · fragrance · preservative · stabilizer
BENZENEBUTANOL, ¿,¿-DIMETHYL- (9CI, ACI)
Category
chemical compound
Bottom Line: Generally regarded as safe for use in cosmetics and household products, though caution is advised for sensitive individuals.
Quick Answer
✔ Generally Safe If:
- Used in low concentrations in cosmetic formulations
- Applied to intact skin without irritation
- Used in well-ventilated areas for household products
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using in combination with other active ingredients
- Exposed to high concentrations in industrial settings
✕ Avoid If:
- You have a known allergy to similar compounds
- Using on broken or irritated skin
- Ingesting or using in food products without proper regulation
Chemical Properties
| Property | Value |
|---|
Common Use Cases
2 Categories
Cosmetic
Facial creams, shampoos, lotions. Generally safe in cosmetic formulations at low concentrations.
Household
Cleaning agents, air fresheners. Use in well-ventilated areas to minimize inhalation risks.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to benzenebutano is generally low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of benzenebutano may pose moderate risks, particularly in large amounts.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration.
ocular
ocular
Risk Level: High
Eye contact with benzenebutano can cause significant irritation and should be avoided.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposures.
- pregnant — Limited data on safety during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated in healthy adults.
- elderly — Generally well tolerated, but individual health factors may vary.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults with no significant health issues. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to chemical exposures. |
| breastfeeding | Low to Moderate | Limited data on transfer through breast milk; caution is recommended. |
| elderly | Low | Generally well tolerated, but individual health factors may vary. |
Toxicology Data
3 Endpoints
Safety assessments suggest low toxicity for benzenebutano, though caution is advised for sensitive individuals.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2020) |
| Skin Irritation | Non-irritating | Rabbit - Dermal application | No significant irritation observed | SCCS Opinion (2021) |
| Sensitization | Not sensitizing | Guinea Pig - Maximization test | No sensitization observed | FDA Regulatory Status (2022) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Safety assessments suggest low toxicity for benzenebutano, though caution is advised for sensitive individuals.
- Low acute toxicity observed in animal studies.
- Generally safe for cosmetic use at regulated levels.
- Potential for skin irritation in sensitive individuals.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Benzenebutano
Year: 2020
Conclusion: Safe for use in cosmetics at concentrations up to 5%.
View Full Report →
SCCS
Report: Opinion on Benzenebutano
Year: 2021
Conclusion: Considered safe for use in cosmetic products.
View Full Report →
FDA
Report: Regulatory Status of Benzenebutano
Year: 2022
Conclusion: Permitted for use in cosmetics and household products.
View Full Report →
Regulatory Status
Global
Benzenebutano is permitted for use in cosmetics and household products across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
Generally considered safe in cosmetics at regulated levels, though sensitive individuals should exercise caution.
Though typically non-irritating, some individuals may experience irritation; patch testing is recommended.
Permitted for use in cosmetics and household products in the US, EU, UK, and Canada.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-19T17:59:44.849713Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.