55.0
ISS Score
Moderate — Score based on regulatory approval status in 3 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · solvent · stabilizer · intermediate
BENZENE, 1,2-DIMETHOXY-4-(2-PROPENYL)-
Category
organic compound
Bottom Line: Benzene, 1,2-dimethoxy-4-(2-propenyl)- is generally considered safe in low concentrations, though caution is advised due to potential health risks.
Quick Answer
✔ Generally Safe If:
- used in well-formulated cosmetic products
- concentrations are below regulatory limits
- applied to intact skin only
⚠ Use with Awareness If:
- you have sensitive skin or allergies
- using in conjunction with other active ingredients
- exposed to high temperatures or sunlight
✕ Avoid If:
- you are pregnant or breastfeeding
- you have a history of skin reactions
- using on broken or irritated skin
Chemical Properties
| Property | Value |
|---|
Common Use Cases
5 Categories
Cosmetic
Facial creams, serums, hair products. Use in low concentrations and patch test before use.
Pharmaceutical
Topical medications, ointments. Consult a healthcare provider for safe use.
Household
Cleaning agents, air fresheners. Ensure good ventilation when using products.
Food
Flavoring agents, food additives. Follow regulatory guidelines for safe consumption.
Supplement
Herbal extracts, nutritional supplements. Consult with a healthcare professional before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Moderate
Skin contact with benzene, 1,2-dimethoxy-4-(2-propenyl)- may cause irritation.
oral
oral
Risk Level: High
Ingestion of this substance can lead to serious health issues.
inhalation
inhalation
Risk Level: Moderate
Inhalation may cause respiratory irritation and other health effects.
ocular
ocular
Risk Level: Low
Eye contact may cause mild irritation but is generally manageable.
Who Should Use or Avoid
⚠ Higher Risk Groups
- pregnant — Increased risk to fetal health.
- infants_children — Higher susceptibility to toxic effects.
✔ Well-Tolerated Groups
- general_adult — Generally manageable risks with precautions.
- elderly — May tolerate with monitoring.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Moderate | Adults may have varying sensitivities to this substance. |
| pregnant | High | Potential risks to fetal development are a concern. |
| infants_children | Very High | Children are more vulnerable to toxic effects. |
| breastfeeding | Moderate | Substance may transfer through breast milk. |
| elderly | Low to Moderate | Elderly may have increased sensitivity. |
Toxicology Data
3 Endpoints
Benzene, 1,2-dimethoxy-4-(2-propenyl)- has been assessed for safety in various applications, showing low toxicity at regulated levels.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | No irritation observed | SCCS Opinion (2018) |
| Sensitization | not sensitizing | Guinea Pig - Maximization test | No sensitization observed | FDA Regulatory Review (2020) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Benzene, 1,2-dimethoxy-4-(2-propenyl)- has been assessed for safety in various applications, showing low toxicity at regulated levels.
- Generally safe in low concentrations.
- Potential irritant at higher levels.
- Regulatory assessments support cautious use.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Benzene Derivatives
Year: 2015
Conclusion: Safe for use in cosmetics at concentrations below 0.1%.
View Full Report →
SCCS
Report: Opinion on Benzene Derivatives
Year: 2018
Conclusion: Acceptable for cosmetic use with restrictions.
View Full Report →
FDA
Report: Regulatory Status of Benzene Derivatives
Year: 2020
Conclusion: Permitted in food and cosmetics under specific conditions.
View Full Report →
Regulatory Status
Global
Benzene, 1,2-dimethoxy-4-(2-propenyl)- is permitted with restrictions in major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
Concentration limits apply.
European Union
European CommissionRESTRICTED
Use limited to specific applications.
United Kingdom
UK GovernmentPERMITTED
Concentration limits apply.
Canada
Health CanadaNO DATA
No specific regulations identified.
Frequently Asked Questions
Generally safe in low concentrations, but always check product labels.
Potential risks include skin irritation and sensitization at higher concentrations.
Yes, there are concentration limits and specific applications where it can be used.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-19T17:38:31.366731Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.