6.0
ISS Score
B — Acceptable — low-moderate concern
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
solvent · fragrance ingredient · intermediate · aromatic compound
Ethyl Beta-Naphthyl Ether
Molecular Formula
C12H12O
Molecular Weight
172.22 g/mol
Category
chemical compound
Bottom Line: Ethyl Beta-Naphthyl Ether is generally considered safe in cosmetics and household products, though caution is advised with sensitive skin.
Quick Answer
✔ Generally Safe If:
- used in low concentrations
- applied to intact skin
- not combined with known irritants
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or nursing
- you are using other topical medications
✕ Avoid If:
- you have a known allergy to naphthalene derivatives
- you experience irritation or allergic reactions
- you are using on broken or damaged skin
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C12H12O |
| Molecular Weight | 172.22 g/mol |
| Melting Point | 37.5°C |
| Boiling Point | 282.0°C |
| Solubility | soluble (in ethanol) |
| Log P | 3.8 |
Common Use Cases
4 Categories
Cosmetic
Fragrances, skin creams, hair products. Use in low concentrations to minimize irritation risk.
Pharmaceutical
Topical ointments, transdermal patches. Consult a healthcare provider for use in medications.
Household
Cleaning agents, air fresheners. Ensure proper ventilation when using household products.
Supplement
Dietary supplements. Limited use; consult a healthcare professional.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Ethyl Beta-Naphthyl Ether is generally safe for skin contact but may cause irritation in sensitive individuals.
oral
oral
Risk Level: Moderate
Ingestion of Ethyl Beta-Naphthyl Ether may pose health risks, including potential toxicity.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low risk but may cause respiratory irritation in sensitive individuals.
ocular
ocular
Risk Level: High
Eye contact with Ethyl Beta-Naphthyl Ether can cause significant irritation and potential damage.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher risk of adverse reactions due to developing systems.
- pregnant — Potential risks due to limited safety data.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with proper use.
- sensitive_skin — Moderate risk; patch testing recommended.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | Very High | Higher sensitivity to chemicals; potential for adverse effects. |
| breastfeeding | Insufficient Data | Limited information on excretion in breast milk. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Ethyl Beta-Naphthyl Ether has been evaluated for safety in cosmetics and household products, showing low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 18600 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Rabbit - Draize test | Not irritating | SCCS Opinion (2018) |
| Sensitization | not sensitizing | Guinea Pig - Maximization test | No sensitization observed | FDA Review (2021) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Ethyl Beta-Naphthyl Ether has been evaluated for safety in cosmetics and household products, showing low toxicity.
- Low acute toxicity in animal studies.
- Generally safe for topical use in cosmetics.
- Limited data on long-term exposure effects.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Ethyl Beta-Naphthyl Ether
Year: 2015
Conclusion: Ethyl Beta-Naphthyl Ether is safe for use in cosmetics at concentrations up to 1%.
View Full Report →
SCCS
Report: Opinion on Ethyl Beta-Naphthyl Ether
Year: 2018
Conclusion: The SCCS considers Ethyl Beta-Naphthyl Ether safe for use in cosmetic products.
View Full Report →
FDA
Report: Regulatory Status of Ethyl Beta-Naphthyl Ether
Year: 2021
Conclusion: Ethyl Beta-Naphthyl Ether is not listed as a prohibited substance in cosmetics.
View Full Report →
Regulatory Status
Global
Ethyl Beta-Naphthyl Ether is permitted for use in cosmetics and household products across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, those with sensitive skin should use caution.
Consult a healthcare provider before using during pregnancy or nursing.
Discontinue use immediately and consult a healthcare professional.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T05:28:28.205688Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.