66.0
ISS Score
Moderate — Score based on regulatory approval status in 4 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance agent · preservative · antioxidant · solvent
PHENOL, 2-METHOXY-4-(2-PROPENYL)-, ACETATE
Category
chemical compound
Bottom Line: Generally regarded as safe when used in cosmetics and pharmaceuticals, though caution is advised for sensitive individuals.
Quick Answer
✔ Generally Safe If:
- Used in low concentrations in cosmetic formulations
- Applied to intact skin without irritation
- Used in food products within regulatory limits
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using in combination with other active ingredients
- Pregnant or breastfeeding
✕ Avoid If:
- You have a known allergy to phenolic compounds
- Using on broken or irritated skin
- Consuming in excessive amounts
Chemical Properties
| Property | Value |
|---|
Common Use Cases
4 Categories
Cosmetic
Facial creams, serums, sunscreens. Use in low concentrations to minimize irritation risk.
Food
Flavoring agents, preservatives. Generally safe within established limits.
Pharmaceutical
Topical ointments, medicated creams. Monitor for allergic reactions in sensitive users.
Supplement
Herbal extracts, dietary aids. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to this compound is generally low risk for most individuals.
oral
oral
Risk Level: Moderate
Ingestion may pose moderate risks, particularly in high doses or sensitive individuals.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation risks are typically low to moderate, depending on concentration and duration.
ocular
ocular
Risk Level: High
Eye contact can lead to significant irritation and potential damage; caution is advised.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher risk of adverse effects due to developing systems.
- pregnant — Potential risks to fetal development; use caution.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with proper use.
- breastfeeding — Generally low risk, but consult healthcare provider.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Higher sensitivity in children; potential for adverse effects. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; use with caution. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Phenol, 2-methoxy-4-(2-propenyl)-, acetate is used in various products, with safety assessments indicating moderate concern for sensitive individuals.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | Moderate irritant | Rabbit - Draize test | Irritating to skin | EFSA Opinion (2018) |
| Sensitization | Not sensitizing | Guinea Pig - Maximization test | Not a sensitizer | CIR Safety Assessment (2015) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Phenol, 2-methoxy-4-(2-propenyl)-, acetate is used in various products, with safety assessments indicating moderate concern for sensitive individuals.
- Used in cosmetics and food products.
- Potential for skin irritation.
- Regulatory assessments vary by region.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Phenol Derivatives
Year: 2015
Conclusion: Generally safe for use in cosmetics at recommended concentrations.
View Full Report →
EFSA
Report: Scientific Opinion on the safety of phenolic compounds
Year: 2018
Conclusion: Safe for use in food within specified limits.
View Full Report →
FDA
Report: Regulatory Status of Phenolic Compounds
Year: 2020
Conclusion: Permitted in cosmetics and food under specific regulations.
View Full Report →
Regulatory Status
Global
Generally permitted in cosmetics and food across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
Generally safe for skin use in low concentrations, though sensitive individuals should exercise caution.
Typically safe in food products within regulatory limits, but excessive consumption should be avoided.
Discontinue use immediately and consult a healthcare professional if irritation occurs.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-19T20:28:57.882792Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.