66.0
ISS Score
Moderate — Score based on regulatory approval status in 4 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · solvent · flavoring agent
Isoeugenyl Acetate
Molecular Formula
C12H14O3
Molecular Weight
206.24 g/mol
Category
fragrance
Bottom Line: Isoeugenyl Acetate is generally considered safe for use in cosmetics and food, though some individuals may experience sensitivities.
Quick Answer
✔ Generally Safe If:
- used in low concentrations
- not applied to broken skin
- not used by individuals with known allergies to similar compounds
⚠ Use with Awareness If:
- you have sensitive skin or allergies
- using in combination with other fragrances
- applying to areas with high absorption
✕ Avoid If:
- you are pregnant or breastfeeding without consulting a doctor
- you have a history of fragrance allergies
- using in products for children without guidance
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C12H14O3 |
| Molecular Weight | 206.24 g/mol |
| Solubility | soluble (in ethanol) |
| Log P | 2.4 |
Common Use Cases
4 Categories
Cosmetic
Fragrances, lotions, shampoos. Use in moderation to avoid potential skin irritation.
Food
Flavoring agents, beverages. Generally recognized as safe when used appropriately.
Pharmaceutical
Topical creams, ointments. Consult a healthcare provider for use in medicinal products.
Supplement
Flavoring in dietary supplements. Ensure compliance with dietary supplement regulations.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Isoeugenyl Acetate is generally well tolerated on the skin, with low irritation potential.
oral
oral
Risk Level: Moderate
Ingestion of Isoeugenyl Acetate may cause gastrointestinal irritation; caution is advised.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure may lead to respiratory irritation; use in well-ventilated areas.
ocular
ocular
Risk Level: High
Contact with eyes can cause significant irritation; avoid direct exposure.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity and risk of adverse reactions.
- pregnant — Limited safety data; consult healthcare provider.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with low irritation potential.
- elderly — Generally well tolerated; monitor for reactions.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated; however, individual sensitivities may vary. |
| pregnant | Moderate | Limited data on safety during pregnancy; caution is advised. |
| infants_children | High | Higher sensitivity in young children; potential for adverse reactions. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; use with caution. |
| elderly | Low | Generally well tolerated, but monitor for any adverse effects. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Isoeugenyl Acetate is assessed for safety in cosmetics and food applications, showing low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Rabbit - Dermal | Not a skin irritant | SCCS Opinion (2019) |
| Sensitization | not sensitizing | Guinea Pig - Maximization Test | Not a sensitizer | EFSA Opinion (2018) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Isoeugenyl Acetate is assessed for safety in cosmetics and food applications, showing low toxicity.
- Low acute toxicity in animal studies.
- Generally safe for cosmetic use.
- Potential for skin irritation in sensitive individuals.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Isoeugenyl Acetate
Year: 2015
Conclusion: Safe for use in cosmetics at concentrations up to 1%.
View Full Report →
EFSA
Report: Scientific Opinion on Isoeugenyl Acetate
Year: 2018
Conclusion: Considered safe for use as a food flavoring agent.
View Full Report →
SCCS
Report: SCCS Opinion on Isoeugenyl Acetate
Year: 2019
Conclusion: Safe for use in cosmetic products with restrictions.
View Full Report →
Regulatory Status
Global
Isoeugenyl Acetate is permitted for use in cosmetics and food across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionPERMITTED
Use limited to cosmetic products.
UK
UK GovernmentPERMITTED
Use limited to cosmetic products.
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
Isoeugenyl Acetate may cause irritation in sensitive individuals; patch testing is recommended.
Consult a healthcare provider before using products containing Isoeugenyl Acetate during pregnancy.
Yes, it is permitted as a flavoring agent in food products under regulatory guidelines.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-29T07:13:10.484264Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.