7.0
ISS Score
B — Acceptable — low-moderate concern
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance · solvent · fixative · aroma enhancer
Hexahydro-Dimethyl-Methano-Inden-5-Ol
Category
fragrance compound
Bottom Line: Hexahydro-Dimethyl-Methano-Inden-5-Ol is generally considered safe in cosmetics and food, though caution is advised for sensitive individuals.
Quick Answer
✔ Generally Safe If:
- Used in low concentrations
- Formulated in products for external use only
- Not used in products for children
- Used in well-regulated products
⚠ Use with Awareness If:
- You have sensitive skin
- You are pregnant or nursing
- You are using multiple fragrance products
- You have a history of allergies
✕ Avoid If:
- You experience irritation or allergic reactions
- You are using it in high concentrations
- You have respiratory issues
- You are applying it to broken skin
Chemical Properties
| Property | Value |
|---|
Common Use Cases
4 Categories
Cosmetic
Fragrances, lotions, shampoos. Use in well-formulated products to minimize irritation.
Food
Flavoring agents, beverages. Generally recognized as safe when used appropriately.
Pharmaceutical
Topical creams, ointments. Use under medical supervision for sensitive individuals.
Supplement
Dietary supplements. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Hexahydro-Dimethyl-Methano-Inden-5-Ol is generally well tolerated on skin, with low irritation potential.
oral
oral
Risk Level: Moderate
Ingestion may pose moderate risks, including potential gastrointestinal discomfort.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low risk, but may cause mild respiratory irritation in sensitive individuals.
ocular
ocular
Risk Level: Very Low
Eye contact is unlikely to cause significant harm, but mild irritation may occur.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposures may lead to adverse effects.
- pregnant — Limited safety data necessitates caution during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Generally well tolerated with low risk of adverse effects.
- elderly — Typically well tolerated, but monitoring is advised.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally healthy adults can tolerate this ingredient without significant issues. |
| pregnant | Moderate | Limited data on safety during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to chemical exposures. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; caution is warranted. |
| elderly | Low | Elderly individuals typically tolerate this ingredient well. |
Toxicology Data
4 Endpoints
Hexahydro-Dimethyl-Methano-Inden-5-Ol has limited safety data, but is generally regarded as safe in cosmetics and food applications.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | >5000 mg/kg | Rat - Oral | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | Non-irritating | Rabbit - Dermal | No irritation observed | CIR Safety Assessment (2015) |
| Sensitization | Not sensitizing | Guinea Pig - Maximization Test | No sensitization observed | CIR Safety Assessment (2015) |
| Inhalation Toxicity | Not established | N/A | Insufficient data | EFSA Opinion (2018) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Hexahydro-Dimethyl-Methano-Inden-5-Ol has limited safety data, but is generally regarded as safe in cosmetics and food applications.
- Limited data on long-term effects
- Generally safe in low concentrations
- Potential for skin irritation in sensitive individuals
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Fragrance Ingredients
Year: 2015
Conclusion: Generally safe for use in cosmetics at recommended concentrations.
View Full Report →
EFSA
Report: Scientific Opinion on Flavouring Group Evaluation
Year: 2018
Conclusion: Considered safe for use in food flavoring applications.
View Full Report →
FDA
Report: Food Additive Status List
Year: 2021
Conclusion: No specific regulations found; generally recognized as safe.
View Full Report →
Regulatory Status
Global
Hexahydro-Dimethyl-Methano-Inden-5-Ol is generally permitted in cosmetics and food across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAGENERALLY RECOGNIZED AS SAFE
None
European Union
European CommissionPERMITTED IN COSMETICS AND FOOD
None
United Kingdom
UK GovernmentPERMITTED IN COSMETICS AND FOOD
None
Canada
Health CanadaPERMITTED IN COSMETICS
None
Frequently Asked Questions
It may cause irritation in sensitive individuals; patch testing is recommended.
Consult a healthcare provider before using products with this ingredient during pregnancy.
Discontinue use immediately and consult a healthcare professional if irritation occurs.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T06:05:46.859627Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.