8.0
ISS Score
A- — Good — low to minimal hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
antioxidant · preservative · stabilizer
7-Propan-2-Yl-1,5-Benzodioxepin-3-One
Molecular Formula
C12H14O3
Molecular Weight
206.24 g/mol
Category
chemical compound
Bottom Line: 7-Propan-2-Yl-1,5-Benzodioxepin-3-One is generally considered safe in cosmetics and supplements, though its use in food is less established.
Quick Answer
✔ Generally Safe If:
- used in recommended concentrations
- not combined with known irritants
- applied to intact skin
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or nursing
- you are using other active ingredients
✕ Avoid If:
- you have a known allergy to similar compounds
- you experience irritation or adverse reactions
- you are using it in food products without guidance
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C12H14O3 |
| Molecular Weight | 206.24 g/mol |
| Log P | 2.6 |
Common Use Cases
3 Categories
Cosmetic
Facial creams, serums, moisturizers. Generally safe for topical use; patch test recommended.
Food
Flavoring agents, food additives. Limited data on food safety; consult guidelines.
Supplement
Dietary supplements, herbal products. Use with caution; consult a healthcare professional.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to 7-Propan-2-Yl-1,5-Benzodioxepin-3-One is generally low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of this substance may pose moderate risks, depending on dosage and individual sensitivity.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, but caution is advised in poorly ventilated areas.
ocular
ocular
Risk Level: High
Eye contact with this substance can lead to significant irritation and should be avoided.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Children may experience heightened sensitivity to this substance.
- pregnant — Limited data necessitates caution during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Generally well tolerated with minimal risk.
- elderly — Typically low to moderate risk, but individual responses may vary.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults with no known severe reactions. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | Very High | Children may be more sensitive to the effects of this substance. |
| breastfeeding | Insufficient Data | Insufficient data on safety during breastfeeding. |
| elderly | Low to Moderate | Elderly individuals may have varying sensitivities. |
Toxicology Data
3 Endpoints
7-Propan-2-Yl-1,5-Benzodioxepin-3-One shows potential safety in cosmetics, but food use lacks comprehensive data.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | Not established | Not available | Insufficient data | — |
| Skin Irritation | Non-irritating | Human patch test | Low irritation potential | CIR Safety Assessment (2021) |
| Sensitization | Not sensitizing | Human clinical study | Low sensitization potential | CIR Safety Assessment (2021) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
7-Propan-2-Yl-1,5-Benzodioxepin-3-One shows potential safety in cosmetics, but food use lacks comprehensive data.
- Safety established in cosmetic applications.
- Limited evidence for food safety.
- Supplement use requires caution.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of 7-Propan-2-Yl-1,5-Benzodioxepin-3-One
Year: 2021
Conclusion: Safe for use in cosmetics at recommended concentrations.
View Full Report →
EFSA
Report: Scientific Opinion on 7-Propan-2-Yl-1,5-Benzodioxepin-3-One
Year: 2020
Conclusion: Insufficient data to conclude on food safety.
View Full Report →
FDA
Report: Food Additive Status
Year: 2022
Conclusion: No established safety for food use.
View Full Report →
Regulatory Status
Global
Regulatory status varies; generally safe in cosmetics, unclear for food use. Switch to Detailed mode for full regulatory breakdown.
US
FDANOT LISTED
No established safety for food use.
EU
European CommissionUNDER REVIEW
Pending safety assessment for food use.
UK
UK GovernmentNOT LISTED
No established safety for food use.
CA
Health CanadaNOT LISTED
No established safety for food use.
Frequently Asked Questions
Yes, it is generally considered safe for use in cosmetics at recommended concentrations.
Caution is advised as there is insufficient data on its safety for food use.
Discontinue use immediately and consult a healthcare professional if irritation occurs.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T03:49:56.541189Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.