55.0
ISS Score
Moderate — Score based on regulatory approval status in 4 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
solvent · fragrance ingredient · stabilizer · intermediate
CYCLOPENTANONE, 2-[2-(4-METHYL-3-CYCLOHEXEN-1-
Category
fragrance
Bottom Line: Cyclopentanone, 2-[2-(4-methyl-3-cyclohexen-1-yl)ethyl] is generally considered safe in cosmetics and household products, though caution is advised for sensitive individuals.
Quick Answer
✔ Generally Safe If:
- used in low concentrations in cosmetic formulations
- applied to intact skin without irritation
- used in well-ventilated areas for household products
⚠ Use with Awareness If:
- you have sensitive skin or allergies
- using in combination with other fragrances
- exposed to high concentrations in industrial settings
✕ Avoid If:
- you are pregnant or nursing without consulting a doctor
- you have a known allergy to similar compounds
- using in products intended for children
Chemical Properties
| Property | Value |
|---|
Common Use Cases
2 Categories
Cosmetic
Fragrances, lotions, shampoos. Generally safe in cosmetics; patch test recommended.
Household
Air fresheners, cleaning products. Use in well-ventilated areas to minimize inhalation risks.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Cyclopentanone may cause mild irritation upon skin contact in some individuals.
oral
oral
Risk Level: Moderate
Ingestion of cyclopentanone can lead to gastrointestinal discomfort and potential toxicity.
inhalation
inhalation
Risk Level: Moderate
Inhalation of vapors may cause respiratory irritation and should be avoided in poorly ventilated areas.
ocular
ocular
Risk Level: High
Contact with eyes can cause significant irritation and potential damage; immediate rinsing is advised.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposures.
- pregnant — Limited data on safety during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with proper use.
- elderly — Generally safe but monitor for sensitivity.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to chemical exposures. |
| breastfeeding | Moderate | Potential for transfer through breast milk is unclear. |
| elderly | Low to Moderate | Elderly individuals may have increased sensitivity. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Cyclopentanone, 2-[2-(4-methyl-3-cyclohexen-1-yl)ethyl] has been evaluated for safety in cosmetics and household products, showing moderate safety.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 18600 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2018) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | Not a skin irritant | SCCS Opinion (2019) |
| Sensitization | not sensitizing | Guinea Pig - Maximization test | No sensitization observed | EFSA Opinion (2020) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Cyclopentanone, 2-[2-(4-methyl-3-cyclohexen-1-yl)ethyl] has been evaluated for safety in cosmetics and household products, showing moderate safety.
- Used primarily for fragrance in various products.
- Moderate safety profile based on available assessments.
- Caution advised for sensitive individuals.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Fragrance Ingredients
Year: 2018
Conclusion: Safe for use in cosmetics at concentrations up to 5%.
View Full Report →
SCCS
Report: Opinion on Fragrance Ingredients
Year: 2019
Conclusion: Considered safe for use in cosmetics with restrictions.
View Full Report →
EFSA
Report: Scientific Opinion on Flavoring Substances
Year: 2020
Conclusion: Acceptable daily intake established; safe for food use.
View Full Report →
Regulatory Status
Global
Cyclopentanone is permitted in cosmetics and household products with some restrictions in the EU. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionRESTRICTED
Limited use in cosmetics
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
Generally, cyclopentanone is considered safe in cosmetics when used at recommended concentrations.
While generally non-irritating, some individuals may experience sensitivity; patch testing is advised.
In the EU, its use is restricted in cosmetics to a maximum concentration of 5%.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-19T18:47:49.890304Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.