56.0
ISS Score
Moderate — Score based on regulatory approval status in 4 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance agent · antimicrobial agent · anti-inflammatory agent · decongestant · aromatic agent
Eucalyptus Globulus Oil
Also known as: Eucalyptus Oil, Eucalyptus Globulus Leaf Oil
Category
essential oil
Bottom Line: Eucalyptus Globulus Oil is generally considered safe for topical use, though it may cause irritation in some individuals when used improperly.
Quick Answer
✔ Generally Safe If:
- diluted properly in carrier oils for topical application
- used in small amounts in food products
- not applied to broken skin
- used in well-ventilated areas to avoid inhalation issues
⚠ Use with Awareness If:
- you have sensitive skin or allergies
- you are pregnant or breastfeeding
- you are using it in aromatherapy
- you have asthma or respiratory issues
✕ Avoid If:
- you are allergic to eucalyptus or related plants
- you have a history of seizures
- you are using it on children under 2 years old
- you are taking medications that may interact
Chemical Properties
| Property | Value |
|---|---|
| Solubility | soluble in alcohol and oils, insoluble in water |
Common Use Cases
4 Categories
Cosmetic
Facial creams, shampoos, body lotions. Dilute before applying to skin to avoid irritation.
Food
Flavoring agents, herbal teas. Use in moderation as a flavoring agent.
Pharmaceutical
Cough syrups, topical ointments. Follow dosage instructions to avoid toxicity.
Supplement
Essential oil capsules, herbal supplements. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Eucalyptus Globulus Oil is generally safe for skin contact but may cause irritation in sensitive individuals.
oral
oral
Risk Level: Moderate
Ingestion of Eucalyptus Globulus Oil can be toxic in large amounts and may cause gastrointestinal issues.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation of Eucalyptus oil is generally safe but may cause respiratory irritation in sensitive individuals.
ocular
ocular
Risk Level: High
Contact with eyes can cause significant irritation and should be avoided.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Young children are at higher risk of toxicity from Eucalyptus oil.
- pregnant — Pregnant individuals should use caution due to limited safety data.
✔ Well-Tolerated Groups
- general_adult — Most adults tolerate Eucalyptus oil without significant issues.
- breastfeeding — Generally safe but should be used with caution.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Most adults tolerate Eucalyptus oil well, but some may experience allergic reactions. |
| pregnant | Moderate | Limited data on the effects during pregnancy; potential risks are not fully understood. |
| infants_children | Very High | Eucalyptus oil can be toxic to young children and should be used with caution. |
| breastfeeding | Low to Moderate | Limited data on safety during breastfeeding; potential for transfer in milk. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation or allergic reactions. |
Toxicology Data
3 Endpoints
Eucalyptus Globulus Oil is widely used for its therapeutic properties, though safety concerns exist regarding its use in certain populations.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 18600 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2012) |
| Skin Irritation | Moderate irritant | Human patch test | Causes irritation in sensitive individuals | SCCS Opinion (2018) |
| Sensitization | Positive in sensitization tests | Guinea pig maximization test | Potential allergen | EFSA Opinion (2017) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Eucalyptus Globulus Oil is widely used for its therapeutic properties, though safety concerns exist regarding its use in certain populations.
- Contains compounds with antimicrobial properties.
- May cause skin irritation or allergic reactions.
- Safety varies based on concentration and method of use.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Eucalyptus Oil
Year: 2012
Conclusion: Eucalyptus oil is safe for use in cosmetics at recommended concentrations.
View Full Report →
SCCS
Report: Opinion on Eucalyptus Oil
Year: 2018
Conclusion: Eucalyptus oil is safe for cosmetic use with restrictions on concentration.
View Full Report →
EFSA
Report: Scientific Opinion on Eucalyptus Oil
Year: 2017
Conclusion: Eucalyptus oil is acceptable for use in food at specified limits.
View Full Report →
Regulatory Status
Global
Eucalyptus Globulus Oil is permitted in most jurisdictions with some restrictions on concentration in cosmetics. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None specified
EU
European CommissionRESTRICTED
Concentration limits in cosmetics
UK
UK GovernmentRESTRICTED
Concentration limits in cosmetics
CA
Health CanadaPERMITTED
None specified
Frequently Asked Questions
While generally safe, it may cause irritation or allergic reactions in sensitive individuals.
Yes, but it should be used in moderation and within recommended limits to avoid toxicity.
Possible side effects include skin irritation, allergic reactions, and respiratory issues if inhaled excessively.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-29T07:06:51.933237Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.