65.0
ISS Score
Moderate — Score based on regulatory approval status in 4 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
solvent · fragrance ingredient · stabilizer · intermediate
CYCLOHEXANOL, 4-(1,1-DIMETHYLETHYL)-
Category
chemical compound
Bottom Line: Cyclohexanol, 4-(1,1-dimethylethyl)- is generally considered safe in cosmetics and household products, though caution is advised for sensitive individuals.
Quick Answer
✔ Generally Safe If:
- Used in low concentrations in cosmetic formulations
- Properly diluted in household products
- Used in well-ventilated areas
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using in combination with other strong chemicals
- Pregnant or nursing women should consult a doctor
✕ Avoid If:
- You have a known allergy to cyclohexanol derivatives
- Using in high concentrations without proper safety measures
- You are using it in poorly ventilated spaces
Chemical Properties
| Property | Value |
|---|
Common Use Cases
3 Categories
Cosmetic
Facial creams, sunscreens, hair conditioners. Generally safe in low concentrations; patch test recommended.
Household
Cleaning agents, air fresheners. Use in well-ventilated areas to minimize inhalation risks.
Pharmaceutical
Topical ointments, medicated creams. Consult a healthcare provider for use in sensitive populations.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Cyclohexanol, 4-(1,1-dimethylethyl)- is generally safe for skin contact but may cause irritation in sensitive individuals.
oral
oral
Risk Level: Moderate
Ingestion of cyclohexanol can lead to gastrointestinal irritation and should be avoided.
inhalation
inhalation
Risk Level: Moderate
Inhalation of vapors may cause respiratory irritation; adequate ventilation is recommended.
ocular
ocular
Risk Level: High
Contact with eyes can cause significant irritation and potential damage; avoid exposure.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher susceptibility to adverse effects; avoid use.
- pregnant — Limited data; caution advised during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Generally well tolerated with proper use.
- sensitive_skin — May tolerate with caution; patch testing recommended.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated by adults; however, individual sensitivities may vary. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | Very High | Children may be more susceptible to adverse effects; avoid use. |
| breastfeeding | Moderate | Potential for transfer through breast milk; limited data available. |
| sensitive_skin | High | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Cyclohexanol, 4-(1,1-dimethylethyl)- has been evaluated for safety in various applications, showing low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 18600 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2012) |
| Skin Irritation | Non-irritating | Rabbit - Draize test | Not a skin irritant | SCCS Opinion (2015) |
| Sensitization | Not sensitizing | Guinea pig - Maximization test | No sensitization observed | EFSA Opinion (2016) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Cyclohexanol, 4-(1,1-dimethylethyl)- has been evaluated for safety in various applications, showing low toxicity.
- Low acute toxicity in animal studies.
- Generally recognized as safe in cosmetics.
- Limited data on long-term exposure effects.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Cyclohexanol
Year: 2012
Conclusion: Safe for use in cosmetics at concentrations up to 5%.
View Full Report →
SCCS
Report: Opinion on Cyclohexanol
Year: 2015
Conclusion: Considered safe for use in cosmetic products.
View Full Report →
EFSA
Report: Scientific Opinion on Cyclohexanol
Year: 2016
Conclusion: No safety concerns at typical exposure levels in food applications.
View Full Report →
Regulatory Status
Global
Cyclohexanol, 4-(1,1-dimethylethyl)- is permitted for use in major jurisdictions with no significant restrictions. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionPERMITTED
None
UK
UK GovernmentPERMITTED
None
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
Yes, cyclohexanol is generally considered safe in cosmetics at low concentrations.
Cyclohexanol is not known to cause skin irritation in most cases, but patch testing is advised.
If you experience any adverse reaction, discontinue use and consult a healthcare professional.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-19T18:40:59.737523Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.