Palermo
EDP Spray

Fragrance Notes

Ambrette (Musk Mallow)BergamotCitrusesLemonMuskMusk and RosePetitgrainPetitgrain and BergamotRose
WomenEau de ParfumCitrus

CA Perfume

Palermo

Inspired by Byredo · Format: EDP Spray

Format
A-
HumanSafe Verified
29 Ingredients Assessed
Generally Safe
74th percentile · No allergens flagged

Safe for everyday use. This product is suitable for most adults in normal fragrance application.

No Banned SubstancesEDP Leave-On Format
Product Safety Score
7.4 / 10
PSSDose-aware safety at actual concentration
Mood Elevation Index™
5.8 / 10
MEI™Fresh mood profile
Environmental Safety
ESSEnvironmental assessment
Evidence Quality
CSSConfidence in evidence base

Why This Score

AMBROXAN (30%) provides a stable, well-tolerated amber base with a high safety score of 7.0/10, making it suitable for regular fragrance use.
D-LIMONENE (8.8%) is a naturally-derived citrus compound commonly used in fragrances; at this concentration it presents moderate safety (ISS 6.8/10).
Sensitive individuals should patch-test before regular use, as D-LIMONENE can trigger contact sensitivity in a small percentage of users, especially on broken skin.

Scores are calculated by HumanSafe™ — an independent third-party platform — using peer-reviewed toxicology sources, regulatory databases, and HumanSafe's Mood Architecture™.

Safety at a Glance

✅ Safe for

  • Daily topical use
  • Most healthy adults
  • Long-term skin contact
  • EDP leave-on format

⚠ Use with care if

  • Sensitive or reactive skin
  • Direct eye-area contact

✕ Avoid if

  • Broken or compromised skin
  • Children under 3 years
Bottom line: Palermo is a citrus eau de parfum with a solid PSS Grade A- (7.1/10), indicating good overall safety for most consumers. Primary concern is D-LIMONENE sensitivity in susceptible individuals.

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Key Factors

Score Drivers
01 / INGREDIENT SAFETY
Formulation Quality
Dose-aware ingredient safety at actual use concentration. 22 ingredients assessed using SCCS opinions, ECHA REACH dossiers, and primary literature.
PSS 7.4
02 / ENVIRONMENTAL
Environmental Safety
Environmental impact at full formulation level — sourcing, biodegradability, and persistence in aquatic systems assessed per REACH and ECHA criteria.
Members only
03 / EVIDENCE QUALITY
Data Confidence
Confidence Substantiation Score — weighted evidence quality from clinical RCTs (A), observational studies (B), expert consensus (C). Higher CSS = more reliable scores.
Members only

Ingredients

29 Total
CAS No.INCI NameFUNCTIONISSStatus
64-17-5EthanolSolvent / Carrier7.0PoorModerate
7732-18-5AquaSolvent / Carrier10.0Low Risk
1222-05-5AmbroxanFragrance ingredient7.0A-Moderate
5989-27-5LimoneneFragrance ingredient7.0CModerate
106-02-5Oxacyclohexadecan-2-OneFragrance ingredient6.6ModerateModerate

24 more ingredients in this formulation

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Ingredients sourced from MG Safety Data Sheet and EU Allergen Certificate. Formulation: fragrance oil 20% + Ethanol 65% + Aqua 15%. ⚑ = EU regulated allergen (Regulation EC 1223/2009). Note 1 = Annex II prohibited substance. Note 2 = commercial quality (includes both isomers).

Fragrance Mood Profile

MEI™ Mood Architecture
Mood Elevation
Index™
5.8
MEI™
Primary Mood
Fresh
Secondary Mood
Romantic
Inner Voice
I am radiant.
CONFIDENCE
5.2
MOOD LIFT
7.0
WARMTH
5.5
ENERGY
3.4
PRESENCE
5.3
IDENTITY
5.4
SOCIAL EASE
6.3

MEI™ scores are calculated by HumanSafe™ using HumanSafe's Mood Architecture™ — a 9-dimension olfactory-emotion mapping system. MEI is an intensity scale: 3/10 = subtle, 9/10 = immersive. Score reflects mood character, not safety.

Usage & Safety Guidance

How to Use
Apply to pulse points — wrists, neck, inner elbow. For Duo Set: oil first, then EDP spray over for superior fixation.
Frequency
Safe for daily use at normal application volumes for healthy adults.
Storage
Room temperature, away from sunlight. Shelf life: 24 months unopened, 12 months after first use.
When to Avoid
Known fragrance allergy. Broken or irritated skin. Children under 3 years.

Safer Alternatives

Higher PSS Score

Products with higher Product Safety Scores. Independently assessed by HumanSafe™.

Frequently Asked Questions

Is Palermo safe for daily use?+

Yes, for most people. The PSS Grade A- score reflects a well-formulated fragrance suitable for regular wear. However, if you have sensitive skin or a history of fragrance allergies, perform a 24-hour patch test on your inner wrist before daily application. If irritation develops, discontinue use.

Are there any ingredients I should watch out for?+

D-LIMONENE is the primary ingredient to monitor. While common in citrus fragrances, it can cause contact dermatitis or allergic reactions in sensitive individuals. AMBROXAN and the other synthetic components score well on safety indices. If you've reacted to citrus fragrances before, consult a dermatologist before using Palermo.

What does a PSS of 7.1/10 (Grade A-) mean?+

The PSS (Product Safety Score) is an independent safety rating where A- indicates above-average safety and tolerability. A score of 7.1/10 suggests the product has passed rigorous ingredient assessment and is suitable for consumer use, though no fragrance is risk-free for all individuals. Those with sensitivities should still exercise caution.

The HumanSafe™ Difference

Most safety tools rate ingredients in isolation — one score regardless of concentration, context, or how the product is used. We assess at actual use concentration.

DimensionOther Apps (EWG, Yuka)HumanSafe™
Dose awarenessSame score regardless of concentrationAssessed at actual use concentration in this product
Exposure contextSame score for rinse-off and leave-on productsAdjusted for product format and absorption rate
AllergensBinary flag — present or absentConcentration compared to IFRA/EU safe limits
Purchase signalScore only, no recommendationClear verdict + safer alternatives ranked by PSS

Version & Audit Trail

Last Updated
April 2026
Scoring Model
PSS v4.1
Data Pipeline
v3.3.2
Status
✓ Verified
VersionDatePSS ScoreISS (avg)Change Summary
v2.1.0April 20267.4Current assessment — PSS v4.1 route-weighted engine. Dose-aware scoring at actual use concentration.
Safety Documents
Safety Data Sheet — EDPCA PS 0920
Available
Download PDF
Safety Data Sheet — OilCA PO 0920
Available
Download PDF
IFRA CertificateCA-0920
Available
Download PDF
Allergen Declaration — EDPCA PS 0920
Available
Download PDF
Allergen Declaration — OilCA PO 0920
Available
Download PDF
Safety Data Sheets are prepared by EMRA LLC for CA Perfume, based on the supplier safety data sheet on file for each fragrance. IFRA and Allergen certificates are original supplier documents on file.
HumanSafe™ is an independent third-party platform. This evaluation is not affiliated with the brand or manufacturer. Scores reflect HumanSafe's proprietary PSS methodology — Ingredient Safety (ISS), Environmental Safety (ESS), and Confidence Substantiation (CSS) — and HumanSafe's Mood Elevation Index™ (MEI™). All scores on a 0–10 display scale. Evidence grades: A=RCT · B=Observational · C=Expert consensus.