Rare Molecules 05
EDP Spray

Fragrance Notes

Cashmeran
Women & MenPerfume OilAromatic

CA Perfume

Rare Molecules 05

Inspired by Escentric Molecules · Format: EDP Spray

Format
A-
HumanSafe Verified
13 Ingredients Assessed
Generally Safe
76th percentile · No allergens flagged

Safe for everyday use. This product is suitable for most adults in normal fragrance application.

No Banned SubstancesEDP Leave-On Format
Product Safety Score
7.6 / 10
PSSDose-aware safety at actual concentration
Mood Elevation Index™
3.9 / 10
MEI™Serene mood profile
Environmental Safety
ESSEnvironmental assessment
Evidence Quality
CSSConfidence in evidence base

Why This Score

Strong safety profile: DIHYDRO PENTAMETHYLINDANONE (20.0%) and 4H-INDEN-4-ONE derivative (17.5%) are the primary components, both rated Grade A with high ingredient safety scores (8.5/10 and 9.0/10 respectively).
Well-established fragrance base: AMBROXAN (15.0%) is a commonly used synthetic musk with a Grade A rating and proven safety history in cosmetic formulations.
Multiple synthetic compounds at elevated concentrations: The formula contains five synthetic aromatic ingredients each above 10%, with the lowest-rated component (OCTAHYDRO-METHOXY-TETRAMETHYL-METHANOAZULENE at 6.0/10) present at 10%. Individuals with sensitive skin or fragrance sensitivities should patch-test before full application.

Scores are calculated by HumanSafe™ — an independent third-party platform — using peer-reviewed toxicology sources, regulatory databases, and HumanSafe's Mood Architecture™.

Safety at a Glance

✅ Safe for

  • Daily topical use
  • Most healthy adults
  • Long-term skin contact
  • EDP leave-on format

⚠ Use with care if

  • Sensitive or reactive skin
  • Direct eye-area contact

✕ Avoid if

  • Broken or compromised skin
  • Children under 3 years
Bottom line: Molecule 05 is an eau de parfum with a Grade A- PSS score (7.6/10) supported by high-safety ingredient ratings. The primary concern is cumulative synthetic fragrance load; those with fragrance sensitivity should exercise caution.

Full breakdown available to members. Join free →

Key Factors

Score Drivers
01 / INGREDIENT SAFETY
Formulation Quality
Dose-aware ingredient safety at actual use concentration. 9 ingredients assessed using SCCS opinions, ECHA REACH dossiers, and primary literature.
PSS 7.6
02 / ENVIRONMENTAL
Environmental Safety
Environmental impact at full formulation level — sourcing, biodegradability, and persistence in aquatic systems assessed per REACH and ECHA criteria.
Members only
03 / EVIDENCE QUALITY
Data Confidence
Confidence Substantiation Score — weighted evidence quality from clinical RCTs (A), observational studies (B), expert consensus (C). Higher CSS = more reliable scores.
Members only

Ingredients

13 Total
CAS No.INCI NameFUNCTIONISSStatus
64-17-5EthanolSolvent / Carrier7.0PoorModerate
7732-18-5AquaSolvent / Carrier10.0Low Risk
33704-61-9Dihydro PentamethylindanoneFragrance ingredient9.0ALow Risk
1222-05-5AmbroxanFragrance ingredient7.0A-Moderate
67874-81-1Octahydro-Methoxy-Tetramethyl-MethanoazuleneFragrance ingredient6.0BModerate

8 more ingredients in this formulation

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Ingredients sourced from MG Safety Data Sheet and EU Allergen Certificate. Formulation: fragrance oil 20% + Ethanol 65% + Aqua 15%. ⚑ = EU regulated allergen (Regulation EC 1223/2009). Note 1 = Annex II prohibited substance. Note 2 = commercial quality (includes both isomers).

Fragrance Mood Profile

MEI™ Mood Architecture
Mood Elevation
Index™
3.9
MEI™
Primary Mood
Serene
Secondary Mood
Romantic
Inner Voice
I am at peace.
CONFIDENCE
3.2
MOOD LIFT
4.4
WARMTH
5.2
ENERGY
1.2
PRESENCE
2.8
IDENTITY
3.6
SOCIAL EASE
4.4

MEI™ scores are calculated by HumanSafe™ using HumanSafe's Mood Architecture™ — a 9-dimension olfactory-emotion mapping system. MEI is an intensity scale: 3/10 = subtle, 9/10 = immersive. Score reflects mood character, not safety.

Usage & Safety Guidance

How to Use
Apply to pulse points — wrists, neck, inner elbow. For Duo Set: oil first, then EDP spray over for superior fixation.
Frequency
Safe for daily use at normal application volumes for healthy adults.
Storage
Room temperature, away from sunlight. Shelf life: 24 months unopened, 12 months after first use.
When to Avoid
Known fragrance allergy. Broken or irritated skin. Children under 3 years.

Safer Alternatives

Higher PSS Score

Products with higher Product Safety Scores. Independently assessed by HumanSafe™.

Frequently Asked Questions

Is Molecule 05 safe for daily use?+

Yes, Molecule 05 is generally safe for daily use based on its Grade A- PSS rating and ingredient safety scores. However, fragrances are personal-use products; some individuals may experience irritation or sensitization with daily application depending on skin type and fragrance tolerance. Start with limited exposure and discontinue if redness, itching, or burning occurs.

Are there any ingredients I should watch out for?+

All five primary ingredients carry Grade A or Grade A- safety ratings. The main consideration is that this formulation is synthetically complex—65% of the product consists of five engineered aromatic compounds. People with known fragrance allergies, contact dermatitis, or asthma triggered by scented products should avoid or patch-test this product first.

What does a PSS of 7.6/10 (Grade A-) mean?+

PSS (Product Safety Score) is an independent safety assessment rating. A 7.6/10 Grade A- score indicates that Molecule 05 meets high safety standards with minimal documented toxicological concerns based on its ingredient profile. This is a above-average rating for fragrance products, though it does not eliminate the possibility of individual sensitivity reactions.

The HumanSafe™ Difference

Most safety tools rate ingredients in isolation — one score regardless of concentration, context, or how the product is used. We assess at actual use concentration.

DimensionOther Apps (EWG, Yuka)HumanSafe™
Dose awarenessSame score regardless of concentrationAssessed at actual use concentration in this product
Exposure contextSame score for rinse-off and leave-on productsAdjusted for product format and absorption rate
AllergensBinary flag — present or absentConcentration compared to IFRA/EU safe limits
Purchase signalScore only, no recommendationClear verdict + safer alternatives ranked by PSS

Version & Audit Trail

Last Updated
April 2026
Scoring Model
PSS v4.1
Data Pipeline
v3.3.2
Status
✓ Verified
VersionDatePSS ScoreISS (avg)Change Summary
v2.1.0April 20267.6Current assessment — PSS v4.1 route-weighted engine. Dose-aware scoring at actual use concentration.
Safety Documents
Safety Data Sheet — EDPCA PS 0683
Available
Download PDF
Safety Data Sheet — OilCA PO 0683
Available
Download PDF
IFRA CertificateCA-0683
Available
Download PDF
Allergen Declaration — EDPCA PS 0683
Available
Download PDF
Allergen Declaration — OilCA PO 0683
Available
Download PDF
Safety Data Sheets are prepared by EMRA LLC for CA Perfume, based on the supplier safety data sheet on file for each fragrance. IFRA and Allergen certificates are original supplier documents on file.
HumanSafe™ is an independent third-party platform. This evaluation is not affiliated with the brand or manufacturer. Scores reflect HumanSafe's proprietary PSS methodology — Ingredient Safety (ISS), Environmental Safety (ESS), and Confidence Substantiation (CSS) — and HumanSafe's Mood Elevation Index™ (MEI™). All scores on a 0–10 display scale. Evidence grades: A=RCT · B=Observational · C=Expert consensus.