Cologne 352
EDP Spray

Fragrance Notes

Guaiac WoodJuniperJuniper Berries and Italian LemonLemonLily-of-the-ValleyMuskOrange BlossomOrange Blossom and RoseRoseWhite Cedar Extract and Guaiac WoodWhite Musk
Women & MenPerfume OilCitrus Aromatic

CA Perfume

Cologne 352

Inspired by Ex Nihilo · Format: EDP Spray

Format
A-
HumanSafe Verified
48 Ingredients Assessed
Generally Safe
73th percentile · No allergens flagged

Safe for everyday use. This product is suitable for most adults in normal fragrance application.

No Banned SubstancesEDP Leave-On Format
Product Safety Score
7.3 / 10
PSSDose-aware safety at actual concentration
Mood Elevation Index™
6.4 / 10
MEI™Fresh mood profile
Environmental Safety
ESSEnvironmental assessment
Evidence Quality
CSSConfidence in evidence base

Why This Score

Ethylene Brassylate (10.0%) scores a perfect 10.0/10 on the Ingredient Safety Scale, indicating excellent safety profile for topical fragrance use.
Linalool (7.5%), a naturally-derived citrus component, carries a solid 7.0/10 ISS rating and is widely recognized as safe in cosmetic fragrances.
Tetramethyl Acetyloctahydronaphthalenes comprises 20.0% of the formula—the highest concentration ingredient. While rated Grade A (6.5/10 ISS), individuals with sensitive skin should perform a patch test before full application.

Scores are calculated by HumanSafe™ — an independent third-party platform — using peer-reviewed toxicology sources, regulatory databases, and HumanSafe's Mood Architecture™.

Safety at a Glance

✅ Safe for

  • Daily topical use
  • Most healthy adults
  • Long-term skin contact
  • EDP leave-on format

⚠ Use with care if

  • Sensitive or reactive skin
  • Direct eye-area contact

✕ Avoid if

  • Broken or compromised skin
  • Children under 3 years
Bottom line: Cologne 352 achieves a PSS Grade B (6.8/10), indicating acceptable safety for typical fragrance use. The product contains several well-established fragrance ingredients, though the high concentration of synthetic musks warrants a patch test for sensitive individuals.

Full breakdown available to members. Join free →

Key Factors

Score Drivers
01 / INGREDIENT SAFETY
Formulation Quality
Dose-aware ingredient safety at actual use concentration. 36 ingredients assessed using SCCS opinions, ECHA REACH dossiers, and primary literature.
PSS 7.3
02 / ENVIRONMENTAL
Environmental Safety
Environmental impact at full formulation level — sourcing, biodegradability, and persistence in aquatic systems assessed per REACH and ECHA criteria.
Members only
03 / EVIDENCE QUALITY
Data Confidence
Confidence Substantiation Score — weighted evidence quality from clinical RCTs (A), observational studies (B), expert consensus (C). Higher CSS = more reliable scores.
Members only

Ingredients

48 Total
CAS No.INCI NameFUNCTIONISSStatus
64-17-5EthanolSolvent / Carrier7.0PoorModerate
7732-18-5AquaSolvent / Carrier10.0Low Risk
54464-57-2Tetramethyl AcetyloctahydronaphthalenesFragrance ingredient7.0BModerate
105-95-3Ethylene BrassylateFragrance ingredient10.0A+Low Risk
78-70-6LinaloolFragrance ingredient7.0A-⚑ EU Allergen

43 more ingredients in this formulation

See Full Ingredient List — Join Free →

Ingredients sourced from MG Safety Data Sheet and EU Allergen Certificate. Formulation: fragrance oil 20% + Ethanol 65% + Aqua 15%. ⚑ = EU regulated allergen (Regulation EC 1223/2009). Note 1 = Annex II prohibited substance. Note 2 = commercial quality (includes both isomers).

Fragrance Mood Profile

MEI™ Mood Architecture
Mood Elevation
Index™
6.4
MEI™
Primary Mood
Fresh
Secondary Mood
Romantic
Inner Voice
I am radiant.
CONFIDENCE
5.8
MOOD LIFT
7.1
WARMTH
6.7
ENERGY
3.4
PRESENCE
6.0
IDENTITY
6.2
SOCIAL EASE
7.0

MEI™ scores are calculated by HumanSafe™ using HumanSafe's Mood Architecture™ — a 9-dimension olfactory-emotion mapping system. MEI is an intensity scale: 3/10 = subtle, 9/10 = immersive. Score reflects mood character, not safety.

Usage & Safety Guidance

How to Use
Apply to pulse points — wrists, neck, inner elbow. For Duo Set: oil first, then EDP spray over for superior fixation.
Frequency
Safe for daily use at normal application volumes for healthy adults.
Storage
Room temperature, away from sunlight. Shelf life: 24 months unopened, 12 months after first use.
When to Avoid
Known fragrance allergy. Broken or irritated skin. Children under 3 years.

Safer Alternatives

Higher PSS Score

Products with higher Product Safety Scores. Independently assessed by HumanSafe™.

Frequently Asked Questions

Is Cologne 352 safe for daily use?+

Cologne 352's Grade B PSS score suggests it is acceptable for regular fragrance application by most adults. However, daily use depends on individual skin sensitivity. If you have reactive or compromised skin, start with limited application and monitor for irritation. Always ensure adequate ventilation when applying fragrances.

Are there any ingredients I should watch out for?+

The primary ingredient, Tetramethyl Acetyloctahydronaphthalenes (a synthetic musk), represents 20% of the formula. While safety-rated, synthetic musks can accumulate in the body with prolonged, heavy exposure. Individuals with fragrance sensitivities, asthma, or migraines should patch-test first and consider limiting frequency of use.

What does a PSS of 6.8/10 (Grade B) mean?+

The Product Safety Score (PSS) is an independent assessment of overall fragrance safety based on ingredient profiles and concentrations. A Grade B (6.8/10) indicates the product meets standard safety expectations for cosmetic fragrances but is not in the highest safety tier. It is suitable for typical consumer use with standard precautions (patch testing, avoiding contact with eyes and broken skin).

The HumanSafe™ Difference

Most safety tools rate ingredients in isolation — one score regardless of concentration, context, or how the product is used. We assess at actual use concentration.

DimensionOther Apps (EWG, Yuka)HumanSafe™
Dose awarenessSame score regardless of concentrationAssessed at actual use concentration in this product
Exposure contextSame score for rinse-off and leave-on productsAdjusted for product format and absorption rate
AllergensBinary flag — present or absentConcentration compared to IFRA/EU safe limits
Purchase signalScore only, no recommendationClear verdict + safer alternatives ranked by PSS

Version & Audit Trail

Last Updated
April 2026
Scoring Model
PSS v4.1
Data Pipeline
v3.3.2
Status
✓ Verified
VersionDatePSS ScoreISS (avg)Change Summary
v2.1.0April 20267.3Current assessment — PSS v4.1 route-weighted engine. Dose-aware scoring at actual use concentration.
Safety Documents
Safety Data Sheet — EDPCA PS 0943
Available
Download PDF
Safety Data Sheet — OilCA PO 0943
Available
Download PDF
IFRA CertificateCA-0943
Available
Download PDF
Allergen Declaration — EDPCA PS 0943
Available
Download PDF
Allergen Declaration — OilCA PO 0943
Available
Download PDF
Safety Data Sheets are prepared by EMRA LLC for CA Perfume, based on the supplier safety data sheet on file for each fragrance. IFRA and Allergen certificates are original supplier documents on file.
HumanSafe™ is an independent third-party platform. This evaluation is not affiliated with the brand or manufacturer. Scores reflect HumanSafe's proprietary PSS methodology — Ingredient Safety (ISS), Environmental Safety (ESS), and Confidence Substantiation (CSS) — and HumanSafe's Mood Elevation Index™ (MEI™). All scores on a 0–10 display scale. Evidence grades: A=RCT · B=Observational · C=Expert consensus.