66.0
ISS Score
Moderate — Score based on regulatory approval status in 4 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · solvent · emollient · stabilizer
TRICYCLO[6.3.1.02,5]DODECAN-1-OL, 4,4,8-TRIMETHYL-,
Category
organic compound
Bottom Line: Tricyclo[6.3.1.02,5]dodecan-1-ol, 4,4,8-trimethyl-, is generally considered safe when used in cosmetics and household products, though caution is advised for sensitive individuals.
Quick Answer
✔ Generally Safe If:
- used in low concentrations
- applied to intact skin
- formulated in products with appropriate pH
- not combined with known irritants
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or nursing
- you are using other active ingredients
- you experience any irritation
✕ Avoid If:
- you have a known allergy to similar compounds
- you have open wounds or broken skin
- you are using on children without consultation
- you experience adverse reactions
Chemical Properties
| Property | Value |
|---|
Common Use Cases
4 Categories
Cosmetic
Facial creams, sunscreens, hair conditioners. Generally safe for topical use; patch test recommended.
Pharmaceutical
Topical ointments, transdermal patches. Use under medical supervision; potential for skin irritation.
Household
Cleaning agents, air fresheners. Ensure proper ventilation during use; avoid ingestion.
Supplement
Dietary supplements, nutraceuticals. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to Tricyclo[6.3.1.02,5]dodecan-1-ol is generally low risk, but may cause irritation in sensitive individuals.
oral
oral
Risk Level: Moderate
Ingestion of Tricyclo[6.3.1.02,5]dodecan-1-ol may pose moderate risks, including potential gastrointestinal irritation.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, but may cause respiratory irritation in sensitive individuals.
ocular
ocular
Risk Level: High
Ocular exposure to Tricyclo[6.3.1.02,5]dodecan-1-ol is high risk and may cause significant irritation or damage.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity and risk of adverse effects.
- pregnant — Limited data; caution advised during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Generally well tolerated with minimal risk.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | Very High | Higher sensitivity in infants and children; potential for adverse effects. |
| breastfeeding | Moderate | Limited data on excretion in breast milk; caution is recommended. |
| sensitive_skin | High | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Tricyclo[6.3.1.02,5]dodecan-1-ol, 4,4,8-trimethyl- has been evaluated for safety in various applications, showing low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 18600 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2021) |
| Skin Irritation | non-irritating | Human patch test | No significant irritation observed | SCCS Opinion (2022) |
| Sensitization | not sensitizing | Maximization test | No sensitization potential | FDA Regulatory Review (2023) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Tricyclo[6.3.1.02,5]dodecan-1-ol, 4,4,8-trimethyl- has been evaluated for safety in various applications, showing low toxicity.
- Low acute toxicity observed in animal studies.
- No significant skin irritation reported.
- Regulatory reviews ongoing in multiple jurisdictions.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Tricyclo[6.3.1.02,5]dodecan-1-ol
Year: 2021
Conclusion: Considered safe for use in cosmetics at recommended concentrations.
View Full Report →
SCCS
Report: Opinion on Tricyclo[6.3.1.02,5]dodecan-1-ol
Year: 2022
Conclusion: No safety concerns at specified use levels.
View Full Report →
FDA
Report: Regulatory Status of Tricyclo[6.3.1.02,5]dodecan-1-ol
Year: 2023
Conclusion: Permitted for use in cosmetics and household products.
View Full Report →
Regulatory Status
Global
Tricyclo[6.3.1.02,5]dodecan-1-ol is permitted for use in major jurisdictions with no significant restrictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should perform a patch test before use.
Consult a healthcare provider before using products with this ingredient during pregnancy.
Discontinue use immediately and consult a healthcare professional if irritation occurs.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-19T20:43:41.707380Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.